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(2) Preclinicalclinical disconnect: dosing regimens (e.g., colchicine microneedles) lack human PK/PD validation, while transdermal hydrogels need human skin permeability studies to address species-specific stratum corneum variability

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Exendin-4 exposure resulted in a significant increase in PKA-specific MIC19 phosphorylation, an effect that was potentiated by the adenylate cyclase activator forskolin (Fig

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