For individuals with more metabolic resistance (pre-diabetes, metabolic syndrome, polycystic ovarian syndrome [PCOS]) GLP-1/GIP can have even greater effects on body weight, cardiovascular health, diabetes prevention, and overall improvement in health markers than GLP-1 alone
it may be another medical factor standing in the way
Pharmacovigilance and Spontaneous Reporting (FAERS) FAERS disproportionality analyses have reported increased reporting odds ratios for thyroid cancer with GLP-1 medications
Many patients avoid topiramate entirely once optimized on the right GLP-1 medication for their genetics
Yo-ung apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice
Many patients find that reaching their therapeutic sweet spot requires 1.02.4 mg weekly, and cost remains flat across all dose levels