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The benefit was not observed in all-cause death (HR 0.99, 95% CI 0.841.15), hospitalization for heart failure (HR 1.04, 95% CI 0.891.22), cardiovascular death (HR 0.95, 95% CI 0.791.16), myocardial infarction (HR 0.88, 95% CI 0.711.08), stroke (HR 1.03, 95% CI 0.751.43) and death or hospitalization for HF (HR 1.07, 95% CI 0.781.46)

Bergenin (BER), a glycoside derivative of trihydroxybenzoic acid, exhibits antioxidant, anti-inflammatory, and hepatoprotective activities (Salimo et al., 2023)

Notably, two studies reported that insulin treatment is associated with a higher risk of DPN (39)

doi: 10.1038/79254 21 RenquistBJMurphyJGLarsonEAOlsenDKleinRFEllacottKLJet al

The experimenter was blinded to the dug condition and the behavioural data analysis

Theyre ideal for people with small, fragile or hard-to-access veins