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"Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial." Lancet , 398(10295), 143-155
Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4
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37 Small molecule GLP-1RAs are chemically synthesized, and compared to protein-based drugs, they generally have smaller molecular sizes
Additionally, research also observed a significant elevation in the levels of TMAO precursors during rosuvastatin treatment
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