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Notably, the pathways of cysteine/methionine metabolism, nicotinate and nicotinamide metabolism, and purine metabolism are highlighted, with specific proteins and metabolites acting as central nodes

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Injections usually contain higher doses and are administered less frequently, often once a week or biweekly

Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

The lack of a bacterial growth inhibitor in sterile water mandates its disposal post a single use to avert microbial contamination

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