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Next, we selected the marketed covalent BTK inhibitor ibrutinib ( 11 ) as a benchmark scaffold and synthesized its carbonyl and thiocarbonyl -haloacetamide derivatives ( 12 - 15 ) corresponding to the electrophiles of fragments 3 - 6 (Fig

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One of them is a phenomenon known as refractoriness, which refers to a reduced or altered responsiveness of skin cells upon repeated UV exposure

The SAM transporter (SAMT) has been identified in Arabidopsis by Figure 1 , transporter 7)