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Overcoming platinum and parp-inhibitor resistance in ovarian cancer

The homozygous null mutation in mice is somewhat more severe than the dominant-negative effect in humans because the loss of collagen III protein is complete in the mouse

For a deeper understanding of why this diluent dominates peptide protocols, read the full breakdown on how much bacteriostatic water to add to peptides

A second Lys to Arg substitution at position 34 eliminates a potential competing acylation site, ensuring homogeneous conjugation exclusively at Lys26 and simplifying downstream purification

doi: 10.1016/j.arr.2007.04.004

Storey: Grants