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These changes impair dynamic joint stabilization and contribute to further joint instability and pain, forming a deleterious feedback loop with intra-articular degeneration (Table 1) (Cruz Ayala et al., 2022

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KAT6A has been shown to bind DNA at unmethylated CpG islands via the first of its two amino-terminal winged helix domains (WHD [Becht et al, 2023

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