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For example, a study published in the New England Journal of Medicine found that participants who stopped semaglutide regained most of the weight they had lost within a year

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This makes them particularly interesting for women who are overweight, have PCOS, or have diabetes and are preparing for pregnancy or fertility treatments

Semaglutide also targets the hypothalamus (a part of your brain) by affecting neurons (nerve cells) within the brain that control appetite

Physical Activity: Regular exercise complements the appetite-suppressing effects of GLP-1 agonists

Other possible effects include injection-site reactions, itching, rash, swelling, or changes in the skin where injections are repeated