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Because the biologically active species is the copper complex, a product that is only partially chelated will produce inconsistent and sometimes much weaker results

When injected systemically, BPC-157 migrates preferentially to areas of tissue damage throughout the body

What evidence does not show: Uncontrolled or pathological collagen overproduction

The histidine residue provides the primary copper-binding site through its imidazole nitrogen, with additional coordination from the peptide backbone and the amino terminus

That's mechanistic relevance, established in non-skin research, not a demonstrated rosacea outcome

In fact, it has many benefits for skin health when used consistently