Lifestyle modifications first
Week 36: Weight loss continued to 21.1% average, though the rate began slowing
Reusing needles increases infection risk, causes more pain (the needle tip dulls after a single use), and can contaminate your vial when you draw the next dose
As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34
This isn't a stall it's expected
A 72-week, double-blind phase 2 trial showed that once-daily administration of semaglutide had a significant therapeutic effect on NASH (193)