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BPC-157 stimulates angiogenesis via the VEGF (Vascular Endothelial Growth Factor) and eNOS (endothelial nitric oxide synthase) pathways, increasing NO production, which promotes vasodilation and the formation of new capillaries

[See Tutorial on SBIR Data Rights] In this overview of the DoW Instructions document, what has been highlighted are some unique features of DoW that become apparent when reviewing the solicitation

Y-X S, Konopleva M, Munsell M, Marini FC, Steelman LS, McCubrey JA, Andreeff M

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Patients who were excluded included those with resection occurring more than 12 weeks before randomization, autoimmune disease, use of systemic glucocorticoids, previous systemic therapy for melanoma, and an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score higher than 1