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i , Six residues around the intracellular ionic lock of GLP-1R (H180 2.50b , L251 3.54b , L349 6.40b , S350 6.41b , T353 6.44b and Y402 7.57b ) were selected to calculate the solvent-accessible surface areas (SASA) using the program freeSASA 49

( b ) Immunoblot of the indicated proteins in cells transduced with shRNA targeting IDH1 (shIDH1) and supplemented with KG, l-carnitine (l-Carn), or O-acetyl-l-carnitine (Ac-Carn)

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In light of the aforementioned safety considerations, the FDA has issued warnings regarding drugs like tofacitinib, highlighting the risks associated with cardiovascular events, thrombosis, and malignancies