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FIGURE 2 6 Conclusion and future perspectives Therapeutic approaches to address oxidative stress typically involve upregulating antioxidant signals such as NRF2, administering exogenous antioxidants, supplementing trace elements or nutrients, and implementing environmental interventions ( de novo GSH synthesis but also exhibits independent antioxidant effects

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Treat claims that confidently assert either "this definitely happens" or "this definitely doesn't happen" with the same scepticism: neither is something the current evidence can support

4A, B), whereas NRF2 ectopic overexpression increased the expression of CBS along with antioxidant factors such as NQO1 and GCLC (Fig

Secondly, the incorporation of active targeting mechanisms enhances the precision with which drugs are delivered to the liver [132]