Key Takeaways: DSIP has limited human sleep research, but the studies are old, small, short-term, and mixed
Frontiers in Endocrinology, 10
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10.1056/NEJMoa1901118 [DOI] [PubMed] [Google Scholar] 31.Yamada Y, Katagiri H, Hamamoto Y et al (2020) Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial
Mechanistic studies indicate that exercise-induced muscle contraction promotes the release of myokines (e.g., IL-6), which inhibit nuclear translocation of NF-B in hepatic Kupffer cells (Figure 2) (Milkovic et al., 2023)
This could pave the way for an entirely new approach in treating obesity-related metabolic disorders, said Dr