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Studies have mapped VDR binding sites across the genome, revealing 2776 loci occupied by VDR following calcitriol stimulation, with 229 genes showing significant expression changes in response to vitamin D [37]

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It says these may indicate nutrient deficiency, dehydration, or an individual intolerance

These concerns necessitate further research, including dedicated long-term safety studies in animal models, specifically designed to assess potential risks associated with higher doses and prolonged exposure