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RSL3 is a chloroacetamide-containing covalent ligand with two stereocenters, with only one of four stereoisomers displaying highly potent GPX4 inhibition 39

The optic nerve, containing over one million nerve fibers connecting the eye to the brain, suffers irreversible damage when deprived of oxygen and nutrients, leading to permanent visual impairment with no effective treatment currently available

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A 32-week study in 84 people with a specific medical condition provides a meaningful signal, not a prescription for the general public

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