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It also improves insulin sensitivity, which helps partition nutrients toward muscle rather than fat storage

Nature medicine , 19 (5), 576585

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

Faster initial response doesn't necessarily predict total weight loss