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Any tendency for melanocytes to spread towards the upper reaches of the epidermis (pagetoid spread) is suggestive of malignant change and should be viewed with caution

In preclinical and early human studies, it did not produce meaningful increases in ACTH, cortisol, or prolactin, which distinguishes it from older secretagogues such as GHRP-2 and GHRP-6

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Upton, J.H., Hannen, R.F., Bahta, A.W., Farjo, N., Farjo, B