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Editorial Advisory Board Member, Harvard Health Publishing Some people who struggle with weight loss have been able to find assistance from several FDA-approved weight-loss medications, such as bupropion plus naltrexone (Contrave), phentermine (Adipex-P), phentermine plus topiramate (Qsymia), and orlistat (Xenical, Alli)

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We included studies involving adult participants who were overweight or obese despite T2DM or OHA use, with a trial duration of at least 20 weeks

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When people decide to stop, the effects of the medications are often reversed, and the weight regained can be proportional to the amount lost