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Implications of VNS in obesity, MASLD, MASH, and cancer Given the complex interplay between metabolic dysregulation and obesity-related diseases, including metabolic-associated steatotic liver disease (MASLD), metabolic-associated steatohepatitis (MASH), and cancer, VNS offers a promising avenue for therapeutic intervention: VNS directly addresses the dysregulated energy balance by reducing appetite, enhancing satiety, and promoting metabolic efficiency

Inflammatory marker improvements appear within months

Discontinuation rates due to adverse events were 4.1% (4 mg), 6.9% (9 mg) and 11.3% (12 mg), compared to 4.9% with placebo

Lack of sleep is specifically associated with increased levels of the hormone ghrelin, which increases appetite, and decreased leptin, which decreases feelings of fullness, she explains

Blomberg AJ, Shih YH, Messerlian C, et al

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