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Older subjects, non-White ethnic groups, and those with severe comorbidities are under-represented, which may limit the generalizability of the findings to real-world populations (24)

These medications significantly reduce hunger, cravings, and food-related thoughts

Unlike general obesity, it is not caused by lifestyle or diet it is neurological in origin, driven by a broken brain circuit that signals permanent hunger and suppressed calorie burning

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In contrast, we demonstrated that a single administration of either PNP hydrogel-based semaglutide or liraglutide drug product candidates maintained therapeutically relevant GLP-1 RA serum concentrations throughout the 42-day study in these T2D rats

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