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In mice, aneuploidy increased from approximately 15% to 43% with age, but SIRT2 overexpression lowered spindle defects and misalignment and increased pregnancy rates from 25% to 75% in transgenic females

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Pros and Cons: Pros: Can make the skin tone lighter and more even

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Covington HE 3rd, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O et al (2009)

Deficiency in B12 can lead to neurological problems, such as tingling or numbness in the hands and feet, difficulty walking, and memory impairment