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Tacrolimus: Fluconazole may increase the serum concentrations of orally administered tacrolimus up to 5 times due to inhibition of tacrolimus metabolism through CYP3A4 in the intestines

[7] The relevance of these animal findings to human patients remains uncertain and is the subject of ongoing pharmacovigilance

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Additionally, monoclonal antibodies targeting substances like fentanyl are being developed to block their effects before they reach the brain, potentially reducing overdose risks