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Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane

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For instance, when there is an influx of Ca 2+ in pancreatic cancer cells, specific subunits of ESCRT-III, referred to as CHMPs (charged multivesicular body proteins), particularly CHMP5 and CHMP6, are recruited and assembled at the damaged site, actively contributing to the restoration of membrane integrity in liver and pancreatic cancer cells [143]

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