These combined effects result in several clinically meaningful outcomes: Improved blood sugar control For people with type 2 diabetes, GLP-1s help reduce both fasting and post-meal blood glucose, often allowing for a reduction in other medications
Consequently, misfolded and polyubiquitinated proteins accumulate in the ER, triggering the unfolded protein response (UPR) and, ultimately, neuronal death
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Bellinghieri G, Santoro D, Calvani M, Mallamace A, Savica V
The non-motor symptoms appear before the onset of motor symptoms for many years
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