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Scientists first isolated it from human gastric juices and have been fascinated by its potential ever since

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MTX treatment caused a prominent dilatation of tubules and degeneration in tubular cells, marked vascular and glomerular congestion, dilatation in Bowmans space and inflammatory cell infiltration in the interstitium (Fig

Molecular mimicry, where microbial proteins resemble self-proteins, can trigger autoimmune responses

Driven by renal clearance and cellular uptake

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