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Steady-state drug concentration (AUCt/24) was achieved after 4-5 weeks of once-weekly administration of the drug

doi: 10.3389/fendo.2025.1570603 Received 03 February 2025 Accepted 29 April 2025 Published 21 May 2025 Volume 16 - 2025 Edited by Jared Rutter, The University of Utah, United States Reviewed by Steven Patterson, Glasgow Caledonian University, United Kingdom Elena Jimenez Marti, University of Valencia, Spain Nigel Irwin, Ulster University, United Kingdom Updates Copyright 2025 Koefoed-Hansen, Helsted, Kizilkaya, Lund, Rosenkilde and Gasbjerg

Relationship between the clinical state and intrathyroidal iodine as measured in vivo in man

In some cases, temporary dose reduction followed by slower re-titration can allow better tolerance whilst maintaining therapeutic benefit

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During the loading phase , patients typically receive 1mg of hydroxocobalamin intramuscularly three times per week for two weeks (six injections total)