However, due to concerns for safety, quality, and effectiveness of compounded GLP1RAs, the American Diabetes Association (ADA) has issued guidance recommending switching individuals to different FDA-approved medications to achieve and maintain individualized glucose-lowering, weight management, and/or cardiovascular and kidney risk reduction goals when supply or access is limited [75]
Some patients also find that switching from semaglutide to tirzepatide produces better results if semaglutide alone is insufficient
Less worry
Mesotherapy: A Less Proven Approach Mesotherapy involves injecting substances into the fat layer to supposedly break down fat cells
Discontinuing semaglutide requires a 68 week washout period before glycogen synthesis normalizes, meaning marathon runners must plan cessation at least 1012 weeks before goal races to allow full training resumption
For guidance on the regulation of research compounds in the UK, see the MHRA