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Prostatic cancer multifocality makes accurate clinical staging difficult, and repeated revisions have been undertaken in an effort to optimize prognostic accuracy

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Although we demonstrated our theoretical consideration on GPCR desensitization by limiting to a prototypical desensitization pathway, it is straight-forward to extend our formulation to include other pathways such as phosphorylation by cAMP-induced activation of PKA [73, 74], which requires including a feedback regulation, and dephosphorylation without internalization [56, 75] and so forth