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It is clear that although the production ratio between insulin and C peptide is theoretically 1, the ratio that can be computed between plasma insulin and C peptide concentrations reflects greatly the clearance kinetics of both peptides and represents a clear index between the amount of available insulin in the circulation and its release and activity from the pancreatic cells, the last represented by C peptide

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Zenaro et al., 2017)

On Reddit forums, thousands of users share dosing protocols, supplier names, and anecdotal outcomes for compounds that have never completed Phase 3 clinical trials

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And the failure rate is extremely high