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In contrast, ERK1/2 phosphorylation was not induced at 2436 h and was moderately increased at 4448 h in mutant mice

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To overcome the rapid degradation of GLP-1, two approaches have been developed: 1) GLP-1 receptor agonists resistant to DPP-IV metabolism, and 2) DPP-IV inhibitors to augment the effect of native/endogenous GLP-1

Kidney Int 2020;98(4S):S1115