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Relative viral titer was determined by infecting cells with serially diluted volumes of virus-containing medium and selecting using appropriate selection reagents

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J Mol Biol 425:29732987 Leggio L, Vivarelli S, LEpiscopo F et al (2017) microRNAs in Parkinsons Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

This isn't theoreticalit's demonstrable in substrate availability and downstream signalling

Toxins (Basel) 9:115