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PT-141's MC1R binding affinity is 50-fold lower than its MC4R affinity, meaning the dose required to produce melanogenesis would far exceed the dose that causes intolerable MC4R-mediated side effects like nausea and blood pressure elevation

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Description B12 for Cats (Methylcobalamin) is the neurologically active form of vitamin B12

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Graf ER, Zhang X, Jin S-X, Linhoff MW, Craig AM