Phase 2 results (48 weeks): 1mg dose: 8.7% average weight loss 4mg dose: 17.1% average weight loss 8mg dose: 22.8% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss These numbers came from a 48-week study period, six months shorter than the 72-week SURMOUNT trials
Improved sleep was a secondary outcome in patients whose pain had been disrupting sleep (PMID 6281420)
Wang, W., Vinocur, B
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Patients on HRT may show different genetic predispositions to semaglutide efficacy or side-effect sensitivity, data that helps providers optimize initial dosing and titration schedules
The evidence supports shared decision-making frameworks, where patient needs, procedure timeframes, and other management approaches, such as liquid diets, ultrasound evaluation of the stomach preoperatively, or anaesthetic modification tailored techniques, are considered primary drivers for care rather than rigid guidelines
