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A 2023 review in StatPearls notes that doses exceeding 7 mg/kg IV can induce methemoglobinemia, particularly in G6PD-deficient individuals, and 5 mg/kg may risk serotonin syndrome, particularly when combined with serotonergic drugs

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[DOI] [PubMed] [Google Scholar] 18.Hu J, Wang X, Chen X, et al

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