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In-vitro studies have reported that GHK-Cu can decrease the expression and activity of certain MMPs (like MMP-1 and MMP-2) while increasing the expression of TIMPs (TIMP-1, TIMP-2)

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By testing all of these, they identified one location in the peptide where putting a staple not only improves the molecules stability and helps it get into cells, but also makes it bind even more tightly to Mcl-1