Chemical solvents and heavy metals can harm liver health, especially with prolonged occupational exposure in industries like healthcare, farming, and dry cleaning.50 Substances like trichloroethylene, carbon tetrachloride, toluene, and heavy metals like mercury and cadmium can cause liver damage, including hepatitis, steatosis, and fibrosis 51 52 53
Such off-label use, i.e., made in the absence of an FDA approval for this indication, in itself is reason for carefully conducted, evidence-based clinical trials, say the researchers, who reported results in JAMA Psychiatry
Nature Reviews Molecular Cell Biology
( f ) Acetyl-CoA abundance was assessed in cells transduced with shRNA targeting TMLHE with or without supplementation with the indicated doses of acetate (n = 8 technical replicates representative from 2 independent experiments)
doi: 10.1001/jama.2024.18581 49 DandonaPChaudhuriAGhanimH
Sultan RS