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Figure 7: Recovery of motor functioning in groups of mice administered MSC, G-CSK, and Dihexa, determined by walking track foot prints of normal and sciatic nerve resected limbs

In young rats with scopolamine-induced deficits, all tested Dihexa treatment groups significantly improved water maze performance

The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity

The brain tissue obtained was weighed and PBS was added in order to ensure a weight (g) to volume (mL) ratio of 1:9

Additionally, the research team noted that these improvements were seen when the nootropic was administered in the gastrocnemius in combination with mesenchymal stem cells

However, a central hypothesis presented in this study is that the AT4 receptor system coincides with the HGF/c-Met receptor system