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Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase

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412,413 Fecal microbiota transplantation (FMT) has also been explored as a method to reset gut microbiota composition, demonstrating improvements in metabolic parameters and neuropathic pain in preclinical studies

Since the HL 2 and the H 3 L forms have four protonation isomers (microspecies) each, and the H 2 L form has six microspecies, the molecule has sixteen different protonation states (microspecies) altogether [77]