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Further evaluation for Hirschsprung disease, a spinal cord abnormality, or a metabolic disorder may be warranted in a child with red flags, such as onset before one month of age, delayed passage of meconium after birth, failure to thrive, explosive stools, and severe abdominal distension

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Its clearance can increase due to the saturation of its transport system, particularly at high doses or with chronic supplementation because of the reported skeletal muscle store saturation [23]

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