The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation
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The differentially expressed genes were filtered using the condition Fold change 2 or 2 and the genes that fulfilled that condition were listed (Supplementary Data 13)
