They work in ways that can affect appetite, food intake, blood sugar, and stomach emptying
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Both Tirzepatide and Semaglutide produce these indirect benefits through their weight loss effects
Science 282, 13181321
While semaglutide is deemed safe in general, caution is advised in subjects with elevated risk or history of thyroid cancer, biliary disease, renal failure, pancreatitis, and diabetic retinopathy, Furthermore, due to the increased risk of hyperglycemia, combined use of semaglutide alongside other diabetic treatments must be conducted under close supervision [16]