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FIGURE 5 3.6 FOXO4-DRI promotes apoptosis in senescent cells As established in prior research, FOXO4-DRI competitively binds to p53 with high affinity, thereby disrupting its nuclear interaction with FOXO4

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Luo M, et al

Additionally , RNA transcript levels are tightly regulated , both at the synthesis stage and through carefully controlled degradation mechanisms [5]

In addition, the production of the body's own substance may decrease with age

Target Identification & Validation Target Identification & Validation Its important to lay strong foundations for successful drug discovery at this first stage of the process