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A drug originally designed to combat a life-threatening disease is now being used casually, sometimes without proper medical supervision

In addition to demonstrating improvements in cardiometabolic health without signs of liver damage, animals treated with GLP-1-MK-801 exhibited relatively mild common side effects associated with GLP-1 agonists (nausea) and NMDA receptor antagonists (hyperthermia and hyperactivity)

Imagine turning up the furnace (Retatrutide increasing energy demand) while simultaneously opening the fuel lines wider (AOD-9604 making stored fat more available as fuel)

Medications can assist

On 21 May 2026 , Lilly published the long-awaited topline results from the TRIUMPH-1 Phase 3 trial, and the data is striking: participants on the highest dose lost an average of 28.3% of their body weight at 80 weeks , with 45.3% of patients losing 30% or more a threshold previously only achievable with bariatric surgery

A subset measured by MRI showed liver fat reductions of 44%