The Nausea Amplification GLP-1 receptor agonists cause nausea through multiple pathways
Phase 2 trial in type 2 diabetes (Lancet 2023) showed similar additive benefit for the combination
This work was partially supported by the National Natural Science Foundation of China (82273961, 82073904, 81872915 to M.-W.W., 82273985, 82121005, 81973373 to D.Y., 32200576, 32071203 to L.-H.Z., 82121005 to H.E.X
One mechanism by which the rate of absorption of alcohol could be altered is through peripheral effects on gastric emptying in people taking GLP-1RAs
This means it stays active in your body long enough for once-weekly dosing
233,267 GLP-1 can slow down gastric emptying through its effects on smooth muscles and the nervous system in the gastrointestinal tract