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Concerning the impact of cholecalciferol supplementation (100,000 IU/15 d for three months) on influenza vaccine response (seroprotection and immune response), no significant changes in cathelicidin levels, antibody titer and ROS production in contrast to elevated TGF- plasma levels could be observed in elderly study participants with suboptimal vitamin D levels ( A (TNF- SNP) may exert less TNF- production, which suggests that anti-inflammatory action of vitamin E might be distinct for those being predisposed to higher inflammation rates, as the A allele correlates with higher TNF- levels [289, 290]