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10.1016/j.bbagen.2009.03.002 260
12, 16, 18 A high degree of synergistic enhancement of L-PAM cytotoxicity in the presence of BSO was observed in multidrug-resistant neuroblastoma cell lines, including those that were established at relapse after myeloablative therapy with L-PAM and lines highly resistant to L-PAM due to loss of p53 function, especially at concentrations of L-PAM that were myeloablative
It is suggested that GSSG accumulates because the capacity of GR is insufficient to keep up with H 2 O 2 -detoxifying enzymes, either because the latter have higher capacities or due to redundancy (APx, CAT, PRx)
Vitamin C and infections
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Alexopoulos GS, Vrontou C, Kakuma T, Meyers BS, Young RC, Klausner E, et al
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