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Eli Lillys retatrutide, a triple agonist targeting GLP-1, GIP, and glucagon receptors, remains in Phase 3 TRIUMPH trials as of mid-2026, with NDA submission projected no earlier than Q4 2026
In addition, GLP1-RAs demonstrate numerous cardiovascular protective effects in subjects with or without diabetes
If were slowing the rate of gastric emptying (and thus how quickly the body gets rid of waste), theres going to be a risk of constipation
Secondly, whether lean MASLD patients can benefit from GLP-1RA-related weight loss
Short-acting GLP-1 receptor agonists like exendin-4 and liraglutide have also been shown to disrupt conditioned place preference for alcohol supporting their ability to selectively attenuate the rewarding effects of alcohol (Egecioglu et al