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This pleiotropic efficacy profile has increased GLP-1RA use, with 12% of adults in the United States (US) reporting ever use of GLP-1RAs

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Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity